Progress Toward Tissue-Engineered Heart Valves
نویسندگان
چکیده
منابع مشابه
Recellularization of decellularized heart valves: Progress toward the tissue-engineered heart valve
The tissue-engineered heart valve portends a new era in the field of valve replacement. Decellularized heart valves are of great interest as a scaffold for the tissue-engineered heart valve due to their naturally bioactive composition, clinical relevance as a stand-alone implant, and partial recellularization in vivo. However, a significant challenge remains in realizing the tissue-engineered h...
متن کاملTissue-engineered heart valves.
Currently-used mechanical and biological heart valve prostheses have several disadvantages. Mechanical prostheses, based on carbon, metallic and polymeric components, require permanent anticoagulation treatment, and their usage often leads to adverse reactions, e.g. thromboembolic complications and endocarditis. Xenogenous and allogenous biological prostheses are associated with immune reaction...
متن کاملCurrent Challenges in Translating Tissue-Engineered Heart Valves
OPINION STATEMENT Heart valve disease is a major health burden, treated by either valve repair or valve replacement, depending on the affected valve. Nearly 300,000 valve replacements are performed worldwide per year. Valve replacement is lifesaving, but not without complications. The in situ tissue-engineered heart valve is a promising alternative to current treatments, but the translation of ...
متن کاملEarly in vivo experience with tissue-engineered trileaflet heart valves.
BACKGROUND Tissue engineering is a new approach in which techniques are being developed to transplant autologous cells onto biodegradable scaffolds to ultimately form new functional autologous tissue. Workers at our laboratory have focused on tissue engineering of heart valves. The present study was designed to evaluate the implantation of a whole trileaflet tissue-engineered heart valve in the...
متن کاملTissue engineered heart valves: will a clinical application be possible?
Artificial valves have been used as the ultimate treatment for cardiac valvular diseases with severe morphologic and functional disorders. Currently, artificial cardiac valves are the most widely used artificial organ, but there remain problems, such as materials, opening and closing mechanisms, and distal control. The best artificial organs are considered to function in the same manner as the ...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2014
ISSN: 0735-1097
DOI: 10.1016/j.jacc.2013.11.030